Neuropathic pain can be highly incapacitating, generating limitations in functionality and the well-being of patients.
In Neuropathic Pain patients with partial response to either drug given alone and seek additional pain relief.
For neuropathic pain management, gabapentin is superior to pregabalin with fewer adverse effects, leading to improved patient adherence for long term use.
Safer than Pregabalin + Duloxetine.
Meta analysis of 50 studies found that 50% adverse events were statistically significantly associated with Pregabalin vs 18% with Gabapentin.
Extra caution should be taken while discontinuing duloxetine as it showed strongest disproportionate.
